Mexclav 250mg+62.5mg Tablet | 7pcs

✔️ Side Effects | Mexclav

Common (≥10%)

• Diarrhea (4–11%, depending on duration)

Occasional (1–10%)

• Nausea, vomiting, vaginitis, diaper rash
• Elevated liver enzymes (AST/ALT, alkaline phosphatase)
• Eosinophilia, mild anemia, thrombophlebitis

Rare (<1%)

• Cholestasis, nephritis, prolonged PT/INR, rash, urticaria, colitis, jaundice, dyspnea, Stevens–Johnson syndrome, toxic epidermal necrolysis

Potentially Serious

• Anaphylaxis, pseudomembranous colitis, nephrotoxicity

✔️ Adults & Adolescents | Dosage and Administration

Pharyngitis/Tonsillitis: 250 mg twice daily for 5–10 days

Acute Maxillary Sinusitis: 250 mg twice daily for 10 days

Chronic Bronchitis (acute bacterial exacerbation): 250–500 mg twice daily for 10 days

Secondary Infections of Acute Bronchitis: 250–500 mg twice daily for 5–10 days

Community-Acquired Pneumonia: 250–500 mg twice daily for 5–10 days

Skin & Skin Structure Infections: 250–500 mg twice daily for 10 days

MDR Typhoid Fever: 500 mg twice daily for 10–14 days

Urinary Tract Infections: 250 mg twice daily for 7–10 days

Uncomplicated Gonorrhea: 1000 mg single dose

Lyme Disease: 500 mg twice daily for 20 days

✔️ Dosage and Administration | Pediatric Patients (3 months – 12 years)

• Pharyngitis/Tonsillitis: 20 mg/kg/day in two divided doses for 5–10 days
• Acute Otitis Media / Maxillary Sinusitis / Pneumonia: 30 mg/kg/day in two divided doses for 5–10 days
• MDR Typhoid Fever: 30 mg/kg/day in two divided doses for 10–14 days
• Skin & Skin Structure Infections: 30 mg/kg/day in two divided doses for 10 days
• Urinary Tract Infections: 20 mg/kg/day in two divided doses for 7–10 days

✔️ Drug Interaction

May increase the nephrotoxic potential of aminoglycosides or strong diuretics (e.g., furosemide).

May enhance the effects of oral anticoagulants.

Probenecid delays excretion and elevates serum cefuroxime levels.

May reduce the efficacy of oral contraceptives.

✔️ Contraindications

Known hypersensitivity to cephalosporins or any component of the formulation.

✔️ Precautions & Warnings

Use with caution in patients with severe renal impairment, history of penicillin allergy, during pregnancy, or lactation.

The drug is excreted in breast milk; therefore, it should be used cautiously in nursing mothers.

✔️ Storage:

Store in a cool, dry place below 30°C, protected from light and moisture.